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Melasma Melasma is a chronic form of hyperpigmentation that causes brown or greyish patches on the cheeks, forehead, upper lip, and jawline

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Biochim Biophys Acta 1780:638651 Saito K, Kobayashi M, Gong Z, Tanaka Y, Yamazaki M (1999) Direct evidence for anthocyanidin synthase as a 2-oxoglutarate-dependent oxygenase: molecular cloning and functional expression of cDNA from a red forma of Perillafrutescens

Numerous studies have demonstrated that ERD exerts its antioxidant effects through Nrf2 activation (Lee et al., 2015